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Are Gluten Intake and Anxiety Connected?

In recent years, the connection between diet and mental health has become a focal point in both nutrition and psychology. If you're interested in learning more about mental health and nutrition listen to Mel Robbins Podcast episode. Among various dietary components, gluten, a protein found in wheat, barley, and rye, has garnered significant attention. This interest is particularly centered on the potential relationship between gluten consumption and anxiety disorders. Let's start by understanding what gluten is.

Gluten is a protein composite found in grains like wheat, barley, and rye. It is responsible for the elasticity and chewiness of bread and is a staple in many diets. Gluten is said to be generally safe for most people, but it can cause health issues for individuals with gluten-related disorders such as celiac disease, wheat allergy, and non-celiac gluten sensitivity (NCGS). But how does this impact the brain and more specifically anxiety?


Anxiety disorders, characterized by excessive and persistent worry, are among the most prevalent mental health conditions globally. Anywhere from 3.6 to 18% of global population may be affected by anxiety disorders. Recent research has begun exploring the potential link between gluten intake and heightened anxiety symptoms.


For individuals with celiac disease, consuming gluten triggers an immune response that harms the small intestine. This condition is known to have various psychological effects, including an increased risk of anxiety. A seminal study in "Alimentary Pharmacology & Therapeutics" revealed that anxiety disorders were notably more common in celiac patients compared to the general population (Addolorato et al., 2008). This suggests a potential link between gluten-induced intestinal damage and psychological health. How does this fare for those of us without celiac disease. 


Non-Celiac Gluten Sensitivity (NCGS) is a condition where individuals experience symptoms related to gluten intake, without having celiac disease or wheat allergy. Psychological disturbances, particularly anxiety, have been reported as symptoms of NCGS. A study in "Gastroenterology" demonstrated that a gluten-free diet significantly reduced anxiety in patients with NCGS (Caio et al., 2017). This finding implies that gluten may have a direct or indirect effect on mental health in sensitive individuals.


The gut-brain axis, a complex communication network between the gut and the brain, could be key in understanding the gluten-anxiety relationship. Gluten's influence on gut permeability and microbiota composition might affect this axis, impacting mental health in the process. Research published in "Nutritional Neuroscience" has begun unraveling how alterations in gut microbiota can affect neurological processes, potentially influencing anxiety disorders (Clapp et al., 2017). This emerging field of research suggests that the gut's health directly correlates with mental well-being, possibly explaining the gluten-related anxiety symptoms.

The exploration of gluten's impact on anxiety also leads to a broader discussion about its overall effect on mental health. Several studies have investigated how gluten-related disorders can lead to various neurological and psychological conditions, including depression, schizophrenia, and autism spectrum disorders. While the mechanisms behind these associations are still under investigation, it highlights the significance of diet in mental health.

Individuals with gluten-related disorders often suffer from nutritional deficiencies due to malabsorption, which can adversely affect mental health. For example, deficiencies in B vitamins, iron, and vitamin D have been linked to increased rates of depression and anxiety. Ensuring a nutritionally balanced gluten-free diet may therefore be crucial in managing both physical and mental health for these individuals.

Chronic inflammation, a hallmark of celiac disease and, to some extent, NCGS, is increasingly recognized as a contributing factor to mental health disorders, including anxiety. Gluten-induced inflammation might trigger or exacerbate psychological symptoms in susceptible individuals. Understanding this inflammatory response is critical in comprehending the full scope of gluten's impact on mental health.

Counterpoints and Considerations

While evidence may point towards a connection between gluten and anxiety, particularly in individuals with gluten-related disorders, several counterpoints and considerations must be acknowledged:

  • Correlation vs. Causation: The association between gluten and anxiety in individuals with gluten-related disorders does not inherently imply causation. It is crucial to consider other contributing factors such as genetic predispositions, overall diet, lifestyle, and environmental stressors.
  • The Placebo Effect: The perceived improvement in anxiety symptoms on a gluten-free diet could be partly attributed to the placebo effect. The psychological impact of adopting what is perceived as a healthier diet should not be underestimated.
  • Nutritional Balance: A gluten-free diet, if not well-managed, can lead to nutritional deficiencies. These deficiencies, in turn, could adversely impact mental health, leading to or exacerbating anxiety symptoms. The importance of a balanced diet, whether gluten-free or not, remains paramount.

Practical Implications and Recommendations

For individuals experiencing anxiety, especially those with diagnosed or suspected gluten-related disorders, several practical steps can be taken:

  1. Medical Consultation: Before adopting a gluten-free diet, it is crucial to consult healthcare professionals. This ensures proper diagnosis and management of any underlying conditions.
  2. Holistic Approach: Addressing anxiety requires a multi-faceted approach. Alongside dietary management, other interventions such as therapy, stress management techniques, and, if necessary, medication should be considered.
  3. Nutritional Guidance: For those on a gluten-free diet, seeking advice from a dietitian can help ensure nutritional adequacy, balancing the diet to support both physical and mental health.


The potential connection between gluten intake and anxiety is a complex and multifaceted issue. Current evidence indicates that gluten may exacerbate anxiety symptoms in individuals with celiac disease or NCGS. You may benefit from an elimination diet to determine whether you have a sensitivity to gluten. 

As research in this field continues to evolve, individuals who suspect a link between their gluten intake and anxiety should seek professional advice. An evidence-based, balanced approach is crucial in understanding and managing the potential impact of gluten on mental health.

For more information on performing an elimination diet or simply trying to remove gluten check out Dr. Susan Blum's book The Immune System Recovery Plan.

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Please note we do not make medical recommendations and always recommend you discuss any plans prior to starting with your healthcare provider. Any statements made have not been evaluated by the FDA.


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